Abduct
To move away from the centre line of the
body, or from a neighbouring part.
Ablation
Surgical removal of a body part.
Absorption
The assimilation of substances into cells, either by diffusion
or osmosis.
Actrapid
An insulin product for diabetics.
Acute
A condition with rapid onset or short duration.
Adduct
Moving a limb towards the centre line of the body.
Adeno-
Pertaining to glands.
Adsorption
The attachment of one substance to another, such as
when a liquid bonds with a vapour.
Aetiology
The study of the causes of disease.
Afferent
From the periphery to the centre.
Analeptic
A drug which stimulates the central nervous system.
Analgesia
Relief of pain.
Angi-
Pertaining to a blood vessel.
Anion
A negatively charged ion.
Anodyne
A pain relieving drug.
Ante-
Before.
Anti-
Against.
Antibiotic
A substance which destroys or prevents growth of bacteria.
Anticonvulsant
Substance which relieves convulsions eg, Phenytoln.
Anxiolytic
Substances which relieve anxiety eg, Benzodiazapines
such as Diazepam.
Apheresis
Extraction of a specific component from donated blood,
with the remainder being returned to the donor.
Artefact
Something introduced or made by man, which may create misleading results.
Aspiration
(1) Inhalation, (2) Drawing off fluid from a cavity.
-asthenia
Weakness.
Atoms
- Atomic Number: The number of protons of an element.
- Mass Number (nucleon number, A): The total number of
protons and neutrons in the nucleus of an atom.
- Unified Atomic Mass Unit (Dalton, symbols Da,
u): 1/12 the mass of the nucleus of an atom of Carbon-12.
(Mass of 1 nucleon)
- Atomic Mass: The mass of an isotope of an element, measured
in Atomic Mass Units. (Carbon-12 = 12 AMUs)
- Relative Atomic Mass (Ar) (Old term: Atomic
weight): The ratio of the weighted average mass of all isotopes of an element,
to 1/12 of the mass of an atom of Carbon-12.
- Relative Formula Mass: Of a compound, is the total of the
Relative Atomic Masses (Ar) of all of the atoms in its chemical formula. Eg,
the Mr of Carbon dioxide is 12 (Ar of Carbon)
plus 32 (2 * Ar of O2 = 2 * 16) = 44.
Therefore, one Mole of Carbon Dioxide has a mass of 44g and Relative Formula Mass of 44.
- Relative Molecular Mass (Mr): The same as Relative Formula
Mass, but for a molecule, rather than a compound.
- Molar Mass (M): Mass per mole of a substance, in kilograms per
mole (historically, g/mol). eg, Oxygen is 15.9994 g/mol, and O2 is 31.9988 g/mol.
Autoclave
A device for sterilizing instruments, using high pressure steam.
Bas-
Refers to the base of something.
Becquerel
S.I. derived unit of radiation measurement.
Beta Lactam antibiotics
A family of antibiotics which includes:
- Penicillins
- Cephalosporins
- Cephamycins
- Carbapenems
- Monobactams
- Beta-lactamase inhibitors
Beta-lactam antibiotics inhibit the growth of bacteria by inactivating a set of enzymes
located in the bacterial cell membrane, which are involved in the third stage of cell
wall synthesis.
Blood transfusion
See Anaesthetics
Brady-
Slow.
Cannula
A hollow tube, inserted into a vessel, to allow administration of fluids.
Cata-
Lower/under.
Catheter
A hollow flexible tube for insertion into a body cavity,
duct, or vessel, to allow the drainage of fluids.
Cation
A positively charged ion.
Caudal
Synonym for posterior.
Cefalexin (Cephalexin)
A broad spectrum cephalosporin antibiotic,
used to treat such things as urinary, joint, and bone infections. Cefalexin
prevents bacteria from forming cell walls, which are vital for their survival,
because they keep unwanted substances from entering their cells, and stop the
contents leaking out. Cefalexin impairs the bonds that hold the bacterial cell wall
together. This allows holes to appear in the cell walls, which kills the bacteria.
Cefalexin is one alternative to patients with Penicillin allergy.
Cephal-
Referring to the head.
Cephalad
Towards the head or anterior section.
Cephalosporin
A cephem sub-class of beta-lactam antibiotics, used
as prophylaxis and treatment against Gram-negative and Gram-positive bacteria.
Patients who are allergic to Penicillin, may also be allergic to Cephalosporins.
-centesis
Puncture.
Chole-
Referring to bile/gallbladder.
Chronic
A long lasting disease state.
Cleido-
Referring to the clavicle.
Concentration
The ratio of solute to its solvent. A high ratio means
the solution is concentrated; if the the ratio is low,
then the solution is diluted.
COSHH
Control of Substances Hazardous to Health. A regulation
of the Health and Safety at Work Act. See
Guidelines
Cost-
Referring to the rib.
Cross matching
The testing of compatibility between a sample of
blood from a donor, and the blood of a recipient. The mixed blood is analysed,
by microscope, for clumping of the blood. An absence of clumping indicates a
successsful match. The process takes approximately 40 minutes.
Cruciate
Cross shaped.
Cyst-
Referring to the bladder.
Cyto-
Referring to cells.
Cytology
The study of cells.
Cytotoxic
A toxic effect on cells.
Diffusion
The movement of particles, in a gas or liquid, from
a region of high to low concentrtation.
Displacement Volume
The volume occupied by a powder when
reconstituted with a diluent (solvent). For example, if 250 mg of a drug has a
displacement volume of 0.2 ml, and 4.8 diluent is added to it, then the solulion
formed will be 250 mg in 5 ml.
Dissolving
When a solute becomes a homogenous mixture (solution) with
another substance (solvent). The solute breaks down from a large crystalline
formation, into smaller groups of molecules. For example, in salt water, the water
(solvent) breaks off salt molecules from the lattice of salt crystals. This is achieved
by the natural polarity of water molecules tending to envelope salt molecules.
Dolorimetry
The measurement of pain.
Dys-
Difficult.
Ecto-
Referring to the outside.
-ectomy
Removal of, for example, an organ.
Ectopic
Away from the normal position or place.
Efferent
From the centre to the periphery
EMLA cream
Eutectic Mixture of Local Anaesthetic (lignocaine and
prilocaine): Applied 1-5 hours prior to venepuncture. Once removed, the anaesthetic
effect wears off rapidly within 20-30 minutes. It can cause vasoconstriction, so Ametop
is often preferred, Not suitable for children under 1 year.
Endo-
Referring to the inside.
Enter-
Referring to the intestines.
Epi-
Above.
Eversion
Turning something inside out.
Exo-
Outer.
Excise
To cut something out.
First intention
The healing of a clean wound,
with new tissue formation and minimal scarring.
Fluid challenge
A method of determining hypovolaemia.
More
Foley Catheter
A flexible tube, which is passed through the
urethra, and into the bladder. The tube has two separated channels, or lumens, running
down its length. One lumen is open at both ends, and allows urine to drain out into a
collection bag. The other lumen has a valve on the outside, which connects to a balloon
at the tip; the balloon is inflated with sterile water, when it lies inside the bladder,
in order to stop it from slipping out.
Formalin
Solution of formaldehyde in water, used for preserving body tissue.
Gamgee Tissue
A surgical dressing invented by Dr. Joseph Sampson
Gamgee, Birmingham, in 1880. An absorbent gauze and cotton tissue, for cushioned wound
protection. Gamgee is used for highly exuding wounds, such as cavity and surgical wounds,
and can also be used for basic padding, but is not designed for pressure point protection.
Gastro-
Referring to the stomach.
Group and Save
The determination of a patient´s ABO blood group, and
screening serum for the presence of antibodies to common red cell antigens which
cause transfusion reactions.
For a patient who is not expected to need a blood
transfusion, the group testing will save time, in case a transfusion does become
necessary, because only a cross match test will then be needed. The process takes
approximately 40 minutes. (Use pink topped bottles for sending to blood bank.)
Haem-
Referring to the blood.
Hepato-
Referring to the liver.
Hist-
Referring to tissue.
Histology
The study of tissues.
Hypertonic
Excessive tension of a blood vessel or muscle.
A solution with higher osmotic pressure than normal body fluid.
Iatrogenic
Injury caused by a doctor/practitioner.
Infra-
Beneath.
Insufflation
The act of blowing a substance into the body, such as
breathing gases during IPPV,
or using carbon dioxide to expand the abdominal cavity, during laparoscopic procedures.
Inter-
Amongst.
Intra-
Within.
Intrathecal
Introducing something
into the space under the arachnoid membrane of the brain or spinal cord.
See Spinal anaesthesia
Ion
An atom which has either lost (cation) or gained (anion) an
electron, giving it a positive (cation) or negative (anion) charge.
Isch-
Too little of something.
Iso-
Equal (in pressure, temperature, concentration...).
Isotonic
Substances having equal pressure. Fluids with equal
osmotic pressure eg, saline solution and blood.
Isotope
An instance of a particular atom which varies acording to
the number of neutrons it contains.
-itis
Inflammation.
Juxta-
Adjacent to.
Laparo-
Referring to the abdomen.
Lumen
The space inside a tube.
Masto-
Referring to the breast.
Medicines and Healthcare products Regulatory Agency
The MHRA is the UK Competent Authority for
blood safety. It has responsibility to ensure that there is a mechanism for the
reporting and recording of serious adverse blood reactions and events. This mechanism
is realised by SABRE, an online system which
allows the submission of notifications and subsequent confirmations of blood related
adverse events.
-megaly
Enlarged.
Mento-
Referring to the Mentum (chin).
Molality
The number of Moles of a substance (solute) when contained in 1
kg of solvent.
Molar solution
One mole of solute per litre of solution.
Molarity
The number of Moles of a substance when contained in 1 litre of solution.
Mole
The SI unit of measurement for the amount of substance which contains as
many elementary entities (such as atoms, ions, and electrons) as there are in 12g of
isotope carbon-12. The numerical value of a substance's atomic mass is the same as that of
it's molar mass: the mass of one mole of that substance in grams.
Myo-
Referring to muscle.
Naloxone
An opioid antagonist, which counters
depression of the central nervous system, caused by opioids.
National Institute for Health and Clinical Excellence
NICE is the NHS body
which publishes evidence based opinions and guidelines on healthcare issues, and which
healthcare professionals are expected to take into account when exercising clinical
judgement. Guidelines are available for many
conditions, such as Surgical Site Infections and Inadvertent Hypothermia.
Neuroleptic drugs
Drugs which act on the nervous system.
Newton
Unit of force, which gives a mass of 1 kg an
acceleration of 1 metre per second/per second.
Non Steroidal Anti Inflammatory Drugs (NSAIDs)
A widely used class of drugs which have three main uses...
- Pain relief - particularly post-operatively
- Reduce inflammation
- Reduce temperature (fever)
High risk groups: Heart problems, Strokes, Aged 75+, Diabetics, Smokers, Hypertensives.
Not recommended for: Pregnancy, Breastfeeding, Kidney disease, Liver disease, Stomach ulcers.
Examples: Diclofenac, Ibuprofen, Celecoxib, Aspirin.
Obtund
To deaden or dull the sensitivity of something.
Obturator
Something which closes an opening.
-oma
Referring to a mass, such as a tumour.
Onco-
Suffix for the name of a tumour.
Oncology
The study of tumours.
Oo-
Referring to the ovum.
Opiate
Natural alkaloids from the resin of the opium poppy. Used
in the production of Morphine and Codeine.
Opioids
Chemicals with good analgesic
properties. Opioids bind to opioid receptors, found principally in the central
and peripheral nervous system, and the GI
tract. More Opiods
Orchi-
Referring to the testiss.
Ortho-
Greek: "straight"
Orthogonal
Involving right angles, such as when two things are
perpendicular to each other.
Os-
Referring to bone.
Osmolality
The concentration of osmotically active particles,
in a solution, measured as osmoles of solute, per kg of solvent.
Osmolarity
Osmotic concentration: The
concentration of osmotically active particles, in a solution. Measurement is given as
osmoles of solute per litre of solution.
Osmole
Measurement of the number of moles of a solute which contribute to the
osmotic pressure of a solution.
Osmosis
The diffusion of fluid (the solvent), through a partially permeable
(for the solvent - not the solute) membrane, from a low concentration solution of solutes,
to a higher concentration solution. This movement, driven by the internal energy of the
solute molecules, tends to equalize the concentration of solute on each side, with the
result that the amount of solvent on each side is not equal. Osmosis does not require input
of energy, but does use kinetic energy.
Osmotic pressure
The pressure, which has to be applied to a solution, to prevent the
net flow of solvent across the membrane, thus maintaining equilibrium.
-ostomy
Surgically created opening.
-otomy
Referring to an incision to make an opening.
Oximetry
Measurement of peripheral haemoglobin oxygen saturation,
using an infrared electromagnetic wave sensor.
Pachy-
A thickening.
Partition coefficient
The ratio of the amount of substance, in one phase,
such as liquid or gas, to the amount in another phase, at a particular temperature, with
the two phases being of equal volume, and at equilibrium with each other. The blood:gas
coefficient is the ratio of the amount of anaesthetic in blood and gas, when the two
phases are of equal volume and pressure, and in equilibrium, at 37 degrees C. It is the
partial pressure of the agent in the blood which, at equilibrium, equals the partial
pressure in the brain, that produces anaesthesia.
Agents with a low blood:gas coefficient exert a high partial pressure and, therefore, a
more rapid onset and offset of action. The oil:gas coefficient is an index of potency,
and is inversely related to MAC. According to the Meyer-Overton theory, the action of an
anaesthetic agent is thought to be related to the lipid solubility.
Pascal
Unit of pressure, equivalent to the force of 1 Newton on 1 square metre.
100 kP is equal to 1 Bar. Mean atmospheric pressure, at
mean sea level, is 101.345 kP, which equals
10.334 M/H2O, or
760.15 mm/Hg, or 1.01345 Bar.
Penicillin alternatives
Cephalosporins (Cefuroxime),
Carbapenems (Imipenem and Meropenem), Macrolides (Erythromycin, Clarithromycin),
Vancomycin, Bactrim.
Perle
A capsule of medicine.
Pharmacokinetics
What the body does to a drug, in terms of
absorption, distribution, and elimination, either by metabolism or excretion.
Phleb-
Referring to the veins.
Phren-
Referring to the diaphragm.
-pnea
Referring to the breath.
Posology
The study of drug dosages.
Postpartum
The period shortly after giving birth.
-pril
Antihypertensive drugs - ACE inhibitors.
Pressure
Force per unit area. The standard unit of pressure is the
pascal (Pa), which is equivalent to 1 Newton of force over 1 square Metre.
Standard Atmospheric Pressure (1 atmosphere) is used as a reference for gas
densities and volumes; defined, at sea-level and 273 degrees (Kelvin), as 1.01345
bar, or 101.325 kPa.
Basics ||
Gas pressure ||
Gas laws
Prognosis
Predicted outcome of an illness.
QDS (Quater in Die Sumendus)
Prescription instruction to take 4 times a day.
Rachi-
Referring to the spine.
Radical
Removing rather than treating a problem.
Recrudescence
A resumption of a condition, or symptoms, some
days after a remission period.
Relapse
A resumption of a condition, or symptoms, some
time (weeks/months/years) after a remission period.
Ren-
Referring to the kidneys.
-rrhage
Referring to a discharge.
-rrhea
Referring to a flow.
SABRE
Serious Adverse Blood
Reactions and Events. The system for reporting problems encountered during the
transfusion of blood and blood products.
SABRE
protocol.
Saline solution
Sodium chloride dissolved in water. A 0.9% solution is
isotonic with blood.
Salping-
Referring to the fallopian tubes.
Sarc-
Referring to the flesh.
Scler-
Hard.
Sliding Scale Insulin administration
A regime for intravenous
administration of short-term insulin according to blood glucose levels (eg, 5
mmol/litre), sometimes to supplement long acting insulin. The sliding scale approach
is used when, for example, the diabetic patient is ill, or hospitalised.
Finger prick capillary glucose levels are monitored every 1-2 hours, and the
insulin dose is titrated according to those readings. Because sliding scale insulin
injections are given in reaction to glucose levels, it is not necessary for a Doctor
to be consulted each time.
The sliding scale approach can result in large swings in glucode levels, and does
not prevent high levels of glucose from occurring, because it is not a proactive way
of managing blood glucose levels.
NHS Diabetes
Solubility
The affinity of a solute for a medium, such as blood or fat tissue.
Solution
If two substances are mixed, such that the composition becomes uniform
throughout the mixture, then that is called a homogeneous mixture, or
solution. If the mixture does not have a uniform composition, throughout the sample, it
is called a heterogeneous mixture. Solutions can contain solid, liquid, or gas components,
or a combination of these phases. See also Dissolving
Solvent
The component of a solution which is present in the greatest amount.
Soma-
Referring to the body of something.
Specific gravity
The ratio of the density, ρ (rho), of an
object to the density of a reference value, such as water (1 kg/litre).
Spondyl-
Referring to the spine.
Sten-
Narrowness.
Sterets
Brand of alcohol swab for cleaning skin prior to injection.
-stomy
An opening.
Supra-
Over or above.
Sym/syn-
Together.
Tarso-
Referring to the ankle.
Tetracycline
A broad spectrum polyketide antibiotic, typically
used to treat urinary and respiratory tract infections.
Tonicity
The relative concentration of two solutes, in a solution, and
separated by a semi-permeable membrane. Also described as the measure of the effective
osmotic pressure gradient, as defined by the water potential of the two solutions. The
relative concentration determines the direction and amount of diffusion.
The Productive Operating Theatre (TPOT)
Scheme to improve four key
dimensions of quality in Operating Theatres:
- Team performance and staff wellbeing
- Safety and reliability of care
- Value and efficiency
- Patient experience and outcomes
-tripsy
Referring to a crushing.
Vas-
Referring to a vessel.
Vallecula
A crevice, depression, or furrow in something.
Vasopressor
An agent which produces
vasoconstriction - constriction of the blood vessels - with consequent rise in
blood pressure. More Vasopressor
Viscosity
An internal property of a fluid which offers resistance to flow.
Viscus
Pertaining to organs within the body cavites, such as the abdomen.
Zithromax
A macrolide sub-class antibiotic, derived from
Erythromycin, and used for bacterial infections.